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Neurochemical Setpoint

Meaning

The Neurochemical Setpoint is the dynamic equilibrium point of key neurotransmitters and neuromodulators within the central nervous system, which fundamentally dictates an individual’s baseline mood, cognitive function, energy levels, and inherent stress resilience. This delicate setpoint is profoundly influenced by the endocrine system, as circulating hormones like thyroid hormones, cortisol, and sex steroids directly modulate neurotransmitter synthesis, release, and receptor sensitivity. Clinical interventions aim to stabilize and optimize this setpoint to improve mental well-being and cognitive performance, recognizing the intimate and bidirectional connection between hormonal and neurological health.