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Neurobiology of Fatigue

Meaning

The Neurobiology of Fatigue is the scientific study of the complex neurological and neurochemical mechanisms that underpin the subjective sensation of profound physical and mental exhaustion. This field investigates the central and peripheral nervous system factors that contribute to reduced performance, focusing on neurotransmitter depletion, altered brain energy metabolism, and the role of inflammatory cytokines in signaling fatigue to the central command centers. In the context of hormonal health, fatigue is often a clinical manifestation of dysregulated HPA axis function or thyroid imbalance. Understanding these mechanisms is crucial for therapeutic intervention.