Skip to main content

Neurobiological Waste Clearance

Meaning

Neurobiological Waste Clearance refers to the essential physiological processes within the central nervous system responsible for the removal of metabolic byproducts, protein aggregates, and interstitial solutes from the brain parenchyma. This waste includes neurotoxic proteins like amyloid-beta and tau, whose accumulation is implicated in neurodegenerative conditions. The primary mechanism is the glymphatic system, which operates most efficiently during sleep. Effective waste clearance is a critical determinant of neurocognitive health and long-term neurological longevity.