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Neurobiological Signature

Meaning

A distinct, measurable pattern of biochemical, structural, and functional characteristics within the central nervous system that is uniquely associated with a specific physiological state, pathological condition, or behavioral phenotype. This signature can encompass a profile of neurotransmitter levels, receptor densities, regional brain activity, or neurosteroid concentrations, providing an objective, quantifiable marker for a complex state like depression or cognitive decline. Identifying a signature allows for precise, personalized diagnostic and therapeutic targeting.