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Neuroactive Steroid Synthesis

Meaning

Neuroactive Steroid Synthesis is the critical process of generating specialized steroid hormones directly within the central and peripheral nervous systems from cholesterol precursors, largely independent of the classical endocrine glands like the adrenals or gonads. These locally synthesized neurosteroids, such as allopregnanolone and dehydroepiandrosterone (DHEA), act rapidly and potently to modulate neuronal excitability, regulate mood, enhance cognition, and govern sleep architecture. Maintaining robust synthesis is essential for optimal neuroendocrine balance and sustained psychological well-being.