What is the Origin of Neuro-Steroids?

The recognition of Neuro-Steroids emerged from neurochemistry, establishing that neural tissue possesses the enzymatic capability to synthesize steroids, distinct from adrenal or gonadal synthesis pathways. This revealed a localized steroid signaling system.

What is the Mechanism of Neuro-Steroids?

Their operation involves allosteric modulation of ligand-gated ion channels, most notably the GABA-A receptor, which influences inhibitory neurotransmission. By altering receptor function, these steroids directly impact mood, anxiety levels, and cognitive processing, often with rapid onset compared to genomic effects of classical hormones.

Neuro-Steroids ∞ Area

Neuro-Steroids

Meaning

Neuro-Steroids are endogenous steroid molecules, such as allopregnanolone or DHEA, synthesized locally within the central nervous system that function not as classic systemic hormones but as powerful neuromodulators. These compounds exert direct effects on neuronal excitability and synaptic plasticity within the brain. They represent an independent layer of neurochemical regulation.