What is the Origin of Neuro-Steroid Availability?

This combines "neuro," relating to nerves, with "steroid," referring to the class of lipid-soluble hormones, indicating their direct action within neural tissue. Availability speaks to the concentration gradient allowing passage across the blood-brain barrier or local synthesis.

What is the Mechanism of Neuro-Steroid Availability?

Neurosteroids act as positive allosteric modulators of GABA-A receptors, influencing neuronal excitability and reducing excitotoxicity, which contributes to neuroprotection. Furthermore, they can influence the expression of neurotrophic factors, supporting neuronal survival and connectivity. Ensuring appropriate concentrations supports the structural and functional integrity of neural circuits influenced by systemic hormones.

Neuro-Steroid Availability ∞ Area

Neuro-Steroid Availability

Meaning

The concentration and accessibility of neurosteroids, such as allopregnanolone and DHEA-S, within the central nervous system to exert their direct neuromodulatory effects independent of peripheral endocrine signaling. Optimal availability is essential for synaptic plasticity, mood regulation, and cognitive resilience. Deficits here can manifest as altered stress coping mechanisms.