The overarching system of command and communication exerted by the central and peripheral nervous systems over the body’s internal physiological processes, including endocrine secretion, cardiovascular function, and metabolic rate. This control is mediated by a complex network of neurotransmitters, neuropeptides, and autonomic nervous system signaling. Optimal neuro-regulatory control is essential for maintaining systemic homeostasis and adapting effectively to stress.
Origin
This term is a core concept in neuroendocrinology and systems physiology, describing the integrated governance of the body by the nervous system. It combines “Neuro,” referring to the nervous system, with “Regulatory Control,” indicating the management and maintenance of internal balance. The HPA axis and the autonomic nervous system are primary anatomical components of this control.
Mechanism
The mechanism involves the hypothalamus acting as the central integration center, receiving sensory input and coordinating responses via both the rapid, direct neuronal pathways and the slower, more sustained hormonal signaling pathways. For instance, sympathetic nervous system activation rapidly modulates adrenal medulla secretion of catecholamines, while simultaneously influencing the pituitary gland’s release of ACTH. This dual control ensures both immediate and prolonged systemic adaptation to environmental and internal demands.
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