A set of clinically applied strategies, encompassing pharmacological, nutritional, and lifestyle interventions, designed to prevent neuronal damage, preserve neuronal structure, and maintain optimal cognitive function and brain health. These protocols are crucial for mitigating the impact of aging, oxidative stress, and chronic inflammation on the central nervous system. Hormonal balance is a key component, as many hormones have direct neurotrophic and anti-inflammatory effects.
Origin
This term evolved from the field of neurobiology and gerontology, where the goal is to prevent or slow neurodegenerative diseases. ‘Neuro-Protective’ explicitly describes the action of shielding the nervous system from injury. The integration into hormonal health recognizes the profound influence of steroids like estrogen, testosterone, and DHEA on neuronal survival and synaptic plasticity.
Mechanism
The protocols function by multiple, synergistic pathways, including enhancing cerebral blood flow, optimizing mitochondrial function to meet the high energy demands of neurons, and reducing the burden of reactive oxygen species. Hormonal components act by modulating neurotrophic factors, such as BDNF, and reducing microglial activation, which is a key driver of neuroinflammation. Targeted nutrients, like omega-3 fatty acids and specific antioxidants, are also critical for membrane integrity and signaling.
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