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Neuro-Metabolic Flexibility

Meaning

Neuro-Metabolic Flexibility is the integrated physiological capacity of the brain and the body’s peripheral tissues to rapidly and efficiently switch between different fuel sources, primarily glucose and fatty acids, to meet dynamic energy demands. This concept extends metabolic flexibility to the central nervous system, recognizing the brain’s significant energy needs and its reliance on systemic metabolic health. High neuro-metabolic flexibility is a hallmark of optimal longevity, cognitive function, and resilience against conditions like insulin resistance and neurodegeneration.