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Neuro-Metabolic Dialogue

Meaning

The Neuro-Metabolic Dialogue refers to the continuous, bidirectional communication network between the central nervous system, particularly the hypothalamus, and peripheral metabolic organs, such as adipose tissue, liver, and pancreas. This complex signaling system, mediated by hormones, neuropeptides, and nutrient sensors, is essential for maintaining energy homeostasis, regulating appetite, and coordinating the body’s response to nutritional status. Disruptions to this dialogue, often driven by chronic inflammation or hormonal resistance, are central to the pathogenesis of metabolic disorders like obesity and type 2 diabetes. Understanding this dialogue is key to addressing systemic hormonal health.