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Neuro-Metabolic Clearance

Meaning

Neuro-Metabolic Clearance is the physiological process of removing metabolic byproducts and waste molecules from the central nervous system, which is crucial for maintaining optimal neuronal function and preventing neurodegeneration. This clearance mechanism is highly active during sleep, ensuring the efficient elimination of potentially neurotoxic proteins, such as amyloid-beta, that accumulate during periods of wakefulness. Efficient neuro-metabolic clearance is a critical determinant of long-term cognitive health, directly impacting memory consolidation, brain plasticity, and overall neurological resilience. Impairment of this process is increasingly linked to age-related neurological decline.