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Neuro-Immune-Endocrine System

Meaning

The Neuro-Immune-Endocrine System, often abbreviated as the NIE system, is a unified, complex communication network that orchestrates the integrated physiological response to both internal and external stimuli, including stress, infection, and environmental changes. This system highlights the profound, bidirectional signaling pathways between the nervous system (neuro), the immune system (immune), and the hormonal system (endocrine). Recognizing the NIE system as a single functional unit is essential for understanding and treating chronic conditions, as dysregulation in one component inevitably impacts the others, leading to systemic imbalance and disease vulnerability.