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Neuro-Hormonal Feedback Loop

Meaning

The Neuro-Hormonal Feedback Loop describes the bidirectional, self-regulating communication system between the nervous system and the endocrine system, which is essential for maintaining physiological homeostasis. This loop involves the brain (specifically the hypothalamus and pituitary gland) sensing physiological states and releasing neurohormones that signal endocrine glands (like the adrenals, thyroid, and gonads) to secrete peripheral hormones. These peripheral hormones, in turn, circulate back to the brain to modulate further neurohormone release, completing the feedback cycle. Dysregulation in this loop, such as HPA axis dysfunction or thyroid axis impairment, is central to many chronic health conditions and aging processes.