What is the Origin of Neuro-Hormonal Feedback?

This concept is foundational to endocrinology and neuroscience, describing the interconnectedness between the brain's command centers and peripheral endocrine glands. It details how the hypothalamus and pituitary act as intermediaries between neural input and hormonal output. The feedback mechanism ensures proportionality in endocrine responses.

What is the Mechanism of Neuro-Hormonal Feedback?

Neural input, such as stress signals, drives the hypothalamus to release releasing hormones, which stimulate the pituitary gland to secrete tropic hormones. Subsequently, the target gland releases its final hormone, which then travels back to inhibit further release from the hypothalamus and pituitary. This negative feedback cascade ensures that hormone levels remain tightly controlled within narrow, functional limits.

Neuro-Hormonal Feedback

Meaning

Neuro-Hormonal Feedback refers to the essential regulatory loops where the nervous system governs the release of hormones, and conversely, circulating hormones exert influence over neuronal activity and central regulatory centers. This interconnected system maintains physiological stability across varying internal and external conditions. It is the core principle governing axis regulation like the HPA and HPG systems.