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Neuro-Hormonal Axis

Meaning

The Neuro-Hormonal Axis represents the intricate, bidirectional communication and control system linking the nervous system and the endocrine system. This master regulatory network, exemplified by the Hypothalamic-Pituitary-Adrenal (HPA) axis and the Hypothalamic-Pituitary-Gonadal (HPG) axis, integrates external stimuli and internal physiological states to coordinate a unified response. It ensures that neurological signals translate into hormonal output and that hormonal feedback, in turn, influences brain function and behavior. Maintaining the integrity of this axis is fundamental for stress adaptation, metabolic regulation, and reproductive health.