The Neuro-Endocrinology of Aging is the specialized field of study that investigates the complex, reciprocal changes in the nervous and endocrine systems that occur across the lifespan and contribute to senescence. This discipline focuses on the age-related dysregulation of central control centers, particularly the hypothalamus and pituitary gland, and the resulting downstream decline in peripheral hormone production and tissue responsiveness. Understanding this axis is fundamental to longevity medicine. The field seeks to identify the central drivers of hormonal decline.
Origin
This field developed from the confluence of neuroscience and endocrinology, recognizing that the brain and the endocrine glands operate as an integrated system, not as separate entities. The “aging” component highlights the progressive failure of this system’s communication and feedback loops over time, often termed the “hypothalamic clock theory of aging.” It provides a framework for addressing age-related systemic decline.
Mechanism
A central mechanism involves the desensitization and reduced pulsatility of hypothalamic hormone release, such as the diminished secretion of GnRH and Growth Hormone-Releasing Hormone (GHRH). This leads to lower trophic stimulation of the pituitary and subsequent reduced output of peripheral hormones like testosterone, estrogen, and IGF-1. Additionally, chronic stress and inflammation can impair the hypothalamic-pituitary-adrenal (HPA) axis feedback, accelerating neuroendocrine decline and contributing to age-related pathologies.
We use cookies to personalize content and marketing, and to analyze our traffic. This helps us maintain the quality of our free resources. manage your preferences below.
Detailed Cookie Preferences
This helps support our free resources through personalized marketing efforts and promotions.
Analytics cookies help us understand how visitors interact with our website, improving user experience and website performance.
Personalization cookies enable us to customize the content and features of our site based on your interactions, offering a more tailored experience.