What is the Origin of Neuro-Endocrine-Vascular Axis?

This concept is an evolution of the traditional neuroendocrine axis models, such as the HPA and HPG axes, expanding the scope to explicitly include the vascular system as an equally active and responsive component. The integration reflects the modern understanding that hormones and neurotransmitters not only signal between glands but also directly regulate the health and function of the blood vessels supplying those organs.

What is the Mechanism of Neuro-Endocrine-Vascular Axis?

Communication along this axis is mediated by signaling molecules: neurotransmitters from the nervous system, hormones from the endocrine glands, and vasoactive substances from the endothelium. For example, hormones like estrogen and testosterone influence the synthesis of nitric oxide, a key vascular signaling molecule, thereby modulating blood vessel dilation and cerebral perfusion. This complex interplay ensures that high-demand tissues, like the brain, receive the necessary hormonal and metabolic support.

Neuro-Endocrine-Vascular Axis ∞ Area

Neuro-Endocrine-Vascular Axis

Meaning

The Neuro-Endocrine-Vascular Axis is a comprehensive physiological model that describes the essential, integrated, and bidirectional communication network linking the nervous system, the endocrine system, and the vascular system. This axis highlights how neural signals influence hormone release, how hormones modulate neural function, and how both systems collectively regulate vascular tone and cerebral blood flow. Optimal function of this axis is critical for systemic homeostasis, especially cognitive and cardiovascular health.