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Neuro-Endocrine Loops

Meaning

Neuro-Endocrine Loops are the complex, interconnected communication pathways that link the nervous system and the endocrine system, ensuring coordinated physiological responses to internal and external stimuli. These feedback circuits involve the hypothalamus, pituitary gland, and peripheral endocrine organs, such as the thyroid, adrenals, and gonads. The integrity and responsiveness of these loops—like the Hypothalamic-Pituitary-Adrenal (HPA) and Hypothalamic-Pituitary-Gonadal (HPG) axes—are fundamental to maintaining homeostasis, regulating stress, and controlling reproduction. Clinical interventions often target these loops to restore systemic balance.