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Neuro-Endocrine-Inflammatory Axis

Meaning

The Neuro-Endocrine-Inflammatory Axis is a complex, integrated system describing the reciprocal communication and regulatory loops among the nervous, endocrine, and immune (inflammatory) systems. This axis represents a unified physiological response network that governs the body’s adaptation to stress, infection, and environmental challenges. Dysregulation within this axis is a fundamental mechanism underlying many chronic conditions, including autoimmune disorders, metabolic syndrome, and age-related cognitive decline. Understanding its intricate crosstalk is paramount for holistic clinical intervention in hormonal and mental health.