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Neuro-Endocrine-Immune Plasticity

Meaning

Neuro-Endocrine-Immune Plasticity refers to the profound, collective capacity of the interconnected nervous, endocrine, and immune systems to structurally and functionally adapt in response to chronic physiological demands, acute stress, or persistent environmental challenges. This plasticity represents the ability of these three major regulatory networks to reorganize their communication pathways and modulate their output to maintain systemic homeostasis and allostasis. High plasticity is a fundamental marker of biological resilience, adaptive capacity, and overall health in the face of aging and disease processes.