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Neuro-Endocrine Fidelity

Meaning

Neuro-Endocrine Fidelity is the precise and harmonious alignment between the central nervous system (CNS) and the peripheral endocrine system, ensuring that hormonal signaling accurately reflects and appropriately responds to internal and external physiological demands. This clinical concept describes the optimal state of the Hypothalamic-Pituitary-Adrenal (HPA), Hypothalamic-Pituitary-Thyroid (HPT), and Hypothalamic-Pituitary-Gonadal (HPG) axes, where feedback loops are sensitive and reliable. High fidelity indicates robust communication, leading to appropriate hormone secretion, receptor sensitivity, and homeostatic resilience. Low fidelity, often seen in chronic stress or aging, results in dysregulated hormone levels and impaired systemic function.