What is the Origin of Neuro-Endocrine Disruption?

This concept expands upon the initial definition of "endocrine disruption," recognizing that environmental agents do not only target peripheral glands but also the central regulatory centers of the brain. The term is rooted in toxicology and neuroendocrinology, acknowledging the intimate, bidirectional communication between the central nervous system and the endocrine axes. It emphasizes the integrated nature of the neuroendocrine system as a target for chemical toxicity.

What is the Mechanism of Neuro-Endocrine Disruption?

Disruptors operate through several mechanisms, frequently by acting as agonists or antagonists at nuclear hormone receptors for steroids and thyroid hormones, which are abundant in the brain. They can also interfere with the synthesis or metabolism of neurohormones and neurotransmitters that regulate pituitary hormone release, such as dopamine or gonadotropin-releasing hormone. The net effect is a dysregulation of central feedback loops, leading to inappropriate or altered hormonal signaling throughout the body, which can manifest as developmental or behavioral changes.

Neuro-Endocrine Disruption

Meaning

Neuro-Endocrine Disruption is a pathological process where exogenous substances interfere with the delicate, integrated signaling between the nervous and endocrine systems. This interference, often caused by environmental pollutants or endocrine-disrupting chemicals, alters the synthesis, release, transport, binding, or elimination of natural hormones, neuropeptides, or neurotransmitters. The clinical consequence is a perturbation of critical physiological functions, including reproduction, development, metabolism, and stress response.