Neuro-Endocrine Calibration is the process of restoring synchronized, appropriate communication between the central nervous system and the endocrine glands to achieve optimal physiological balance. This involves fine-tuning feedback loops involving the hypothalamus, pituitary, and peripheral endocrine organs in response to internal and external stressors. Successful calibration underpins resilience and stable mood.
Origin
The term merges neuroscience and endocrinology, acknowledging that the brain dictates hormonal release patterns, which in turn influence brain function. Calibration implies an iterative process of measurement and adjustment.
Mechanism
Calibration addresses dysregulation in the HPA axis, where chronic stress can cause hypocortisolism or hypercortisolism, thereby dampening pituitary signaling. Interventions aim to re-sensitize central receptors to circulating hormone levels and modulate neurotransmitter activity that influences GHRH and CRH release, restoring the proper set point for hormonal output.
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