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Neuro-Endo-Metabolic Axis

Meaning

The Neuro-Endo-Metabolic Axis, often abbreviated as the NEM Axis, represents the intricate, bidirectional communication network that integrates the nervous, endocrine, and metabolic systems to maintain systemic homeostasis. This complex axis ensures that the body’s response to stress, energy demands, and environmental cues is finely coordinated at all levels, from cellular physiology to organism-wide behavior. Dysfunction in one component, such as chronic stress affecting the nervous system, inevitably cascades into imbalances in hormonal regulation and metabolic function. Clinically, assessing this axis provides a holistic view of systemic resilience.