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Neuro-Aromatization

Meaning

Neuro-aromatization is the localized conversion of androgens, primarily testosterone, into estradiol by the enzyme aromatase within specific central nervous system (CNS) tissues, including the hypothalamus and limbic structures. This local estrogen synthesis is crucial for modulating neurotransmitter function, regulating body temperature, and influencing sexual behavior independent of peripheral estrogen levels. It highlights the brain’s local steroidogenic capacity.