What is the Origin of Neuro-Active Peptides?

The term combines "Neuro," referring to the nervous system, with "Active Peptides," emphasizing their biological function as signaling molecules. The study of these peptides emerged from the field of neuroendocrinology, recognizing that many hormones and growth factors are also expressed and active within the brain. This discovery expanded the understanding of brain-body communication far beyond traditional neurotransmitters.

What is the Mechanism of Neuro-Active Peptides?

Neuro-Active Peptides exert their effects by binding to specific G-protein coupled receptors or enzyme-linked receptors expressed on neuronal and glial cell membranes. This binding triggers intracellular signaling cascades that alter neuronal excitability, gene expression, and synaptic plasticity. Examples include peptides that modulate the HPA axis (e.g., CRH), regulate appetite (e.g., Neuropeptide Y), or promote neuronal survival (e.g., BDNF-like mimetics). Their precise targeting allows for highly specific therapeutic applications.

Neuro-Active Peptides ∞ Area

Neuro-Active Peptides

Meaning

Neuro-Active Peptides are short chains of amino acids that function as signaling molecules within the central and peripheral nervous systems, modulating a vast array of neurological and physiological processes. These peptides can act as neurotransmitters, neuromodulators, or neurohormones, influencing mood, cognition, pain perception, sleep, and the overall stress response. They represent a distinct class of biological agents with targeted, high-affinity receptor binding, offering precise control over neural function.