What is the Origin of Neuro-Active Compounds?

The concept spans neurochemistry, pharmacology, and endocrinology, acknowledging that a wide range of substances beyond traditional neurotransmitters influence brain function. The term gained broader relevance with the recognition of the gut-brain axis, where microbial metabolites are now understood to be potent neuro-active agents. This highlights a necessary shift towards a systemic and integrated view of neurological health.

What is the Mechanism of Neuro-Active Compounds?

These compounds operate by binding to specific receptors on neuronal or glial cells, leading to either excitatory or inhibitory effects on cellular activity. Hormones, for instance, can act as neuro-active compounds by altering gene expression in neurons or by rapidly modulating membrane excitability. The gut-derived compounds, such as short-chain fatty acids and tryptophan metabolites, cross the blood-brain barrier or signal via the vagus nerve, directly linking peripheral metabolism to central nervous system function.

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Neuro-Active Compounds

Meaning

Neuro-Active Compounds are a diverse class of endogenous and exogenous molecules that possess the ability to influence the function of the nervous system by modulating neurotransmission, neuronal excitability, or neuroendocrine signaling. This category includes classical neurotransmitters, neuropeptides, certain hormones, and metabolites produced by the gut microbiota. Their clinical significance lies in their direct impact on mood, sleep, cognitive function, and the overall stress response, acting as key chemical communicators between the body and the brain.

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HRTioOctober 9, 2025

Neuro-Active Compounds

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