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Neural Substrate Switching

Meaning

Neural Substrate Switching is the adaptive neurobiological process that enables neurons and glial cells in the brain to shift their primary energy source dynamically from glucose to alternative substrates, most notably ketone bodies. This capability is a critical aspect of brain fuel plasticity, providing metabolic protection when glucose supply is compromised or when glucose uptake is impaired, such as in certain neurodegenerative states. The capacity for efficient switching is a key indicator of cognitive reserve and metabolic health in the central nervous system.