What is the Origin of Neural Sensitivity?

The term combines 'neural,' relating to the nervous system, with 'sensitivity,' referring to the capacity to be affected by something. In endocrinology, it highlights the brain's role as a major hormone target organ.

What is the Mechanism of Neural Sensitivity?

Hormones, particularly steroids and thyroid hormones, cross the blood-brain barrier and bind to neuronal receptors, directly altering the transcription of genes involved in synaptic structure and neurotransmitter synthesis. Furthermore, the number and function of postsynaptic receptors, such as those for dopamine or serotonin, determine the efficiency of signal transduction across the synapse, thereby defining the overall neural sensitivity.

Neural Sensitivity ∞ Area

Neural Sensitivity

Meaning

The degree of responsiveness of neurons and neural circuits to incoming stimuli, including neurotransmitters, circulating hormones, and sensory input. Optimized neural sensitivity is essential for rapid cognitive processing, emotional regulation, and efficient communication across the central nervous system. Diminished sensitivity is often a factor in age-related cognitive slowing.