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Neural Scaffolding Proteins

Meaning

Neural Scaffolding Proteins are a diverse class of structural and regulatory proteins concentrated at the postsynaptic density and presynaptic terminals, which function to organize and anchor various components of the synapse. These proteins are essential for establishing the precise spatial arrangement of neurotransmitter receptors, ion channels, and signaling molecules, thereby determining the efficiency and plasticity of synaptic transmission. They are fundamental to the structural integrity and functional capacity of neural circuits. Proper scaffolding is necessary for sustained cognitive function.