Neural Resilience Factors are the intrinsic biological and physiological mechanisms that enable the central nervous system to resist, adapt to, and rapidly recover from various forms of stress, injury, or age-related degeneration. These factors include a robust capacity for neurogenesis, high levels of neurotrophic support, efficient cellular repair, and a regulated inflammatory response. Clinically, optimizing these factors is central to preventive neurology and maintaining long-term cognitive health. They represent the brain’s inherent ability to maintain function despite adversity.
Origin
This concept is derived from neuroscience and stress physiology, where ‘Neural’ refers to the nervous system and ‘Resilience Factors’ denotes the intrinsic elements that confer resistance and recovery capability. The term emphasizes a proactive, protective approach to brain health.
Mechanism
Hormonally, neural resilience is significantly supported by neurotrophins, such as Brain-Derived Neurotrophic Factor (BDNF), which are often regulated by systemic hormones like estrogen and testosterone. These hormones and factors promote the growth and survival of neurons, enhance synaptic function, and reduce the chronic low-grade inflammation that contributes to neuronal vulnerability. The mechanism is centered on sustaining a neurochemically rich environment that continuously supports the structural and functional integrity of the neural architecture.
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