A conceptual term for the combined regenerative processes of adult neurogenesis—the continuous creation of new functional neurons—and enhanced synaptic plasticity within the central nervous system, particularly localized in the hippocampus. It represents the powerful potential for the adult brain to structurally and functionally renew itself in response to positive stimuli and a supportive biological environment.
Origin
This idea stems from breakthrough discoveries in the late 20th century that definitively demonstrated that neurogenesis persists in the adult mammalian brain, a finding that fundamentally contradicted the previous long-held dogma of a static brain. The term ‘rebirth’ emphasizes the profound and clinically relevant regenerative capacity linked to cognitive longevity.
Mechanism
The process of Neural Rebirth is profoundly regulated by the systemic endocrine system; for example, consistent physical activity and specific hormones like Insulin-like Growth Factor 1 (IGF-1) and estrogen actively promote the proliferation and subsequent survival of new neuronal progenitor cells. Optimizing the entire neuroendocrine environment is a key clinical strategy to therapeutically support this vital mechanism of long-term cognitive maintenance and functional repair.
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