What is the Origin of Neural Precursor Proliferation?

This term is derived from developmental and adult neuroscience, where 'Neural Precursors' are the stem-like cells that have the potential to differentiate into neurons or glia. 'Proliferation' is the precise biological term for cell multiplication. Its study in the adult context highlights the ongoing, dynamic nature of brain structure.

What is the Mechanism of Neural Precursor Proliferation?

Proliferation is stringently regulated by a complex network of local and systemic signals. Potent mitogens, including Epidermal Growth Factor (EGF) and Fibroblast Growth Factor (FGF), act locally to stimulate cell division. Furthermore, systemic hormones like estradiol and dehydroepiandrosterone (DHEA) directly enhance the mitotic activity of these precursor cells, thereby providing a crucial endocrine link between systemic health and the rate of new neuron generation.

Neural Precursor Proliferation ∞ Area

Neural Precursor Proliferation

Meaning

The process of mitotic cell division and expansion in the population of undifferentiated progenitor cells residing within the neurogenic niches of the adult brain, such as the hippocampal subgranular zone. This proliferation is the indispensable initial step of adult neurogenesis, supplying the necessary cellular raw material for the generation of new, functionally integrated neurons. It serves as a vital indicator of the brain’s inherent regenerative potential.