The process of structurally and functionally strengthening neuronal connections and supporting glial cell health through optimized physiological conditions, aiming for enhanced signal integrity and resilience against excitotoxicity or oxidative damage. This involves promoting synaptogenesis and maintaining the structural plasticity of the central nervous system. Fortification directly supports long-term cognitive health and adaptability.
Origin
This concept merges terminology from neuroscience (“Neural Network”) with enhancement strategies from applied physiology (“Fortification”). Its origin lies in recognizing that cognitive longevity depends not just on neurotransmitter balance but on the physical architecture of the brain’s wiring, which is highly sensitive to metabolic and hormonal milieu.
Mechanism
Fortification is achieved by ensuring robust delivery of essential building blocks, such as specific fatty acids and amino acid precursors, to the brain tissue. Hormonally, adequate levels of neurosteroids and growth factors, like IGF-1, stimulate the production of BDNF, which is critical for long-term potentiation and synaptic remodeling. Sustained low-grade inflammation, conversely, actively degrades these structures, necessitating strict metabolic control.
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