The inherent, cyclical biological processes within the central nervous system, primarily occurring during sleep, that are essential for cellular waste clearance, synaptic homeostasis, and the repair of neuronal structures. These cycles ensure the sustained functional integrity and long-term health of the brain. Disruption of these cycles is a precursor to neurodegeneration and cognitive decline.
Origin
This term draws from sleep medicine, neurophysiology, and the discovery of the glymphatic system, which actively clears metabolic waste products from the brain. It emphasizes the critical, restorative role of organized biological rhythmicity.
Mechanism
The primary mechanism involves the glymphatic system, which becomes highly active during deep sleep, facilitating the bulk flow of cerebrospinal fluid to clear neurotoxic byproducts like amyloid-beta. Simultaneously, essential hormonal signals, such as melatonin and growth hormone, regulate synaptic pruning and neuronal repair, consolidating memory and preparing the brain for optimal waking performance.
We use cookies to personalize content and marketing, and to analyze our traffic. This helps us maintain the quality of our free resources. manage your preferences below.
Detailed Cookie Preferences
This helps support our free resources through personalized marketing efforts and promotions.
Analytics cookies help us understand how visitors interact with our website, improving user experience and website performance.
Personalization cookies enable us to customize the content and features of our site based on your interactions, offering a more tailored experience.