Neural integration is the fundamental process by which a single neuron combines and sums all the incoming excitatory and inhibitory synaptic signals it receives to determine whether its membrane potential will reach the threshold for generating an action potential. At a macroscopic level, this term refers to the complex communication and coordinated activity across various brain regions and neural networks to produce coherent perception, cognition, and motor behavior. This integration is the essential basis of information processing within the central nervous system.
Origin
This concept is a cornerstone of neurophysiology, stemming from early studies of synaptic transmission and the electrical properties of the neuron. Neural refers to the nerve cells, and integration describes the combining of multiple, disparate inputs to form a single, unified output.
Mechanism
In the individual neuron, spatial and temporal summation of postsynaptic potentials occurs primarily at the axon hillock, determining the cell’s firing decision. Systemically, neural integration involves the synchronized oscillatory activity of interconnected brain circuits, often mediated by gamma and theta rhythms. Neurotransmitters and neuromodulators, whose levels are influenced by hormonal status, fine-tune the excitability and plasticity of these circuits, ensuring efficient and precise communication across vast networks to support complex functions.
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