Neural Connectivity Maintenance is the ongoing physiological process of preserving the structural integrity and functional efficiency of the complex network of synaptic connections between neurons within the central nervous system. This maintenance is fundamental for sustaining all cognitive functions, including memory, processing speed, and executive function, and is a key target in neuro-longevity strategies. Hormones and neurotrophic factors play an indispensable role in promoting synaptic plasticity and preventing age-related structural degradation.
Origin
This concept is a core principle of modern neuroscience, recognizing that the brain’s functional capacity relies on the dynamic, efficient communication pathways between its constituent cells. “Maintenance” highlights the continuous, energy-intensive effort required to preserve these circuits against cumulative damage and decline. Its link to hormonal health stems from the neurotrophic effects of hormones like BDNF, estrogen, and testosterone.
Mechanism
Maintenance involves processes such as neurogenesis, the pruning of weak synapses, and the strengthening of active connections through long-term potentiation (LTP). Key mechanisms include the proper function of glial cells, which support neuronal health, and the sustained signaling of neurotrophic factors. Hormones modulate this by influencing gene expression related to synaptic protein synthesis and reducing the neuroinflammatory environment that can compromise neural circuit integrity.
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