The therapeutic process of achieving and maintaining a state of equilibrium among the critical neurotransmitters and neuromodulators within the central nervous system. Stabilization ensures consistent mood, optimal cognitive function, and predictable stress response by preventing excessive swings in excitatory and inhibitory signaling. This is fundamentally a homeostatic goal for the neuroendocrine system.
Origin
The concept stems from neuropharmacology and psychiatry, where the balance of key brain chemicals like serotonin, dopamine, and GABA is central to mental health. ‘Stabilization’ is the clinical objective, implying a sustained state of functional balance.
Mechanism
Stabilization relies on optimizing the synthesis, release, reuptake, and catabolism of neurotransmitters at the synaptic cleft. Nutritional cofactors, hormonal milieu, and gut microbiota metabolites all critically influence the production and turnover of these chemical messengers. The HPA axis also plays a direct role, as chronic cortisol exposure can disrupt the balance of glutamate and GABA signaling.
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