Neural Architecture Fortification is the process of enhancing the structural robustness and functional connectivity within the brain’s complex network of neurons and glial cells. This involves strengthening synaptic connections, improving myelination integrity, and supporting the overall structural scaffolding that underlies learning and memory. It speaks to building cognitive resilience.
Origin
This concept draws from developmental neuroscience, where activity-dependent plasticity shapes the developing brain, and applies these principles to adult maintenance and repair mechanisms. It reflects a proactive approach to neuroprotection through structural reinforcement. The goal is to create a more resilient wiring diagram.
Mechanism
Fortification is often supported by factors like BDNF and adequate levels of gonadal steroids, which promote synaptogenesis and the survival of existing neuronal connections. Adequate metabolic support, particularly efficient mitochondrial ATP production, provides the energy required for the constant remodeling and maintenance of synaptic structures. This biological reinforcement underpins sustained cognitive performance.
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