What is the Origin of Nettle Root?

The common name Nettle is derived from the Old English netele, and the root has a long history of use in traditional European herbal medicine for a range of conditions, including urinary tract issues. Its modern application in endocrinology and men's health is based on scientific investigation into its molecular components and their specific interaction with steroid hormone metabolism.

What is the Mechanism of Nettle Root?

The mechanism is thought to involve the lignans within the root binding to Sex Hormone-Binding Globulin (SHBG). By occupying the binding sites on SHBG, the lignans may reduce the globulin's affinity for endogenous androgens, such as testosterone. This action potentially leads to a modest increase in the concentration of biologically active, free testosterone in the circulation, while also directly influencing the growth factors involved in prostate cell proliferation.

Nettle Root

Meaning

Nettle Root, derived from the perennial flowering plant Urtica dioica, is a botanical supplement frequently used in hormonal health, particularly for supporting prostate health in men and modulating sex hormone-binding globulin (SHBG) levels. The root extract contains various bioactive compounds, including lignans and sterols, which exert their effects through interactions with hormonal pathways. It is considered a natural adjunct in the management of benign prostatic hyperplasia (BPH).