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Negative Feedback Suppression

Meaning

Negative Feedback Suppression is a fundamental regulatory mechanism within the endocrine system where the high concentration of a circulating hormone acts to inhibit the further release of its upstream regulatory hormones. This biological control system is essential for maintaining hormonal homeostasis and preventing the overproduction or underproduction of hormones. When a therapeutic hormone is administered, the resulting elevation in blood levels can suppress the body’s natural production, which is a key clinical consideration in hormone replacement therapy. Understanding this suppression is vital for managing patient expectations and avoiding iatrogenic endocrine dysfunction.