What is the Origin of NDRG1 Gene?

The gene was first identified as a gene whose expression was down-regulated in N-myc oncogene-transformed cells, hence the name 'N-myc downstream regulated gene.' Its significance in general physiology and oncology has been a focus of molecular biology research for decades. In endocrinology, interest in NDRG1 has grown due to its regulation by and influence on signaling pathways critical to metabolic health, such as those governed by insulin and hypoxia.

What is the Mechanism of NDRG1 Gene?

NDRG1 acts as a stress-response protein, often upregulated under conditions of cellular hypoxia, DNA damage, or specific nutrient deprivation. Its mechanism involves regulating the expression of other genes and proteins, particularly those involved in cellular proliferation and migration. In relation to hormones, NDRG1 is known to be regulated by androgen signaling and may play a role in the progression of hormone-sensitive cancers, indicating a complex and significant interaction with the overall endocrine environment and cellular longevity.

NDRG1 Gene ∞ Area

NDRG1 Gene

Meaning

The NDRG1 gene, or N-myc downstream regulated gene 1, is a protein-coding gene implicated in a diverse array of cellular processes, including cell differentiation, stress response, and tumor suppression. In the context of hormonal health and longevity, NDRG1 expression is often studied for its role as a potential biomarker for cellular stress and its involvement in pathways that regulate iron metabolism and lipid homeostasis, both of which are intimately linked to endocrine function and metabolic aging. Its function suggests a protective role against certain forms of cellular damage.