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Navitoclax

Meaning

Navitoclax is a small-molecule pharmacological agent classified as a selective inhibitor of the anti-apoptotic Bcl-2 family proteins, specifically targeting Bcl-2, Bcl-xL, and Bcl-w. This compound is primarily investigated in oncology for its ability to restore the apoptotic pathway in cancer cells that have become dependent on these anti-death proteins for survival. In the context of longevity and hormonal health, it is a subject of research for its potential senolytic activity, which involves inducing programmed cell death in senescent cells that accumulate with age. Its clinical application requires careful management due to its potent mechanism of action.