What is the Origin of Natural Progesterone?

The term originated to distinguish this bioidentical compound from the various synthetic progestins developed in the mid-20th century. While the source material for pharmaceutical production is typically a plant sterol, the final product is chemically and biologically identical to the human hormone, hence "natural" or "bioidentical." This distinction is crucial in clinical practice due to the differing pharmacological effects and safety profiles between the bioidentical and synthetic forms.

What is the Mechanism of Natural Progesterone?

Natural Progesterone exerts its primary effects by binding with high affinity to the nuclear progesterone receptor (PR), acting as a direct transcription factor to regulate gene expression in target tissues. Its mechanism includes inducing a secretory phase in the endometrium, providing a calming and anxiolytic effect in the brain by modulating GABA receptors, and supporting bone metabolism. It also serves as a precursor for other steroids in the steroidogenesis pathway, contributing to the overall hormonal milieu.

Natural Progesterone

Meaning

Natural Progesterone refers to a pharmaceutical preparation of the progesterone molecule that is chemically identical in molecular structure to the progesterone produced endogenously by the human corpus luteum and adrenal glands. Unlike synthetic progestins, which are chemically modified to alter metabolism and patentability, natural progesterone binds to and activates the body’s progesterone receptors in the exact same manner. Clinically, it is used in hormone replacement therapy for indications such as protecting the endometrium during estrogen therapy, managing perimenopausal symptoms, and supporting reproductive health.