What is the Meaning of Natural Growth Hormone?

Natural Growth Hormone, or Somatotropin, is a single-chain polypeptide hormone produced and secreted by the somatotroph cells of the anterior pituitary gland. Its primary physiological role is to stimulate growth, cell reproduction, and regeneration in humans. Clinically, it is essential for maintaining healthy body composition, bone density, and metabolic function, particularly through its mediation via Insulin-like Growth Factor 1 (IGF-1).

What is the Origin of Natural Growth Hormone?

The term is derived from the Greek soma meaning 'body' and the function of promoting growth. The discovery and subsequent understanding of its pituitary origin and systemic effects marked a major milestone in modern endocrinology. The addition of 'Natural' distinguishes the endogenous, biologically regulated secretion from exogenous therapeutic administration.

What is the Mechanism of Natural Growth Hormone?

Growth Hormone secretion is pulsatile, regulated by the hypothalamic hormones Growth Hormone-Releasing Hormone (GHRH) and Somatostatin. Once secreted, it acts directly on target tissues and indirectly by stimulating the liver to produce IGF-1, which then mediates many of its anabolic effects. This complex neuro-endocrine axis ensures that growth and repair processes are precisely timed, often peaking during deep sleep cycles.

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