What is the Origin of NAD+ Restoration Therapy?

The foundation of this therapy lies in biochemistry and aging research, which identified NAD+ as a critical, rate-limiting molecule for sirtuin and PARP enzyme activity. The clinical translation began with the use of NAD+ precursors, such as Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN), to enhance endogenous synthesis. It represents a targeted, molecular approach to combat the biochemical hallmarks of aging.

What is the Mechanism of NAD+ Restoration Therapy?

NAD+ acts as a primary electron acceptor in glycolysis and the Krebs cycle, making it indispensable for ATP production within the mitochondria. Crucially, it serves as a cofactor for sirtuins, a class of enzymes that regulate gene expression, metabolism, and DNA repair. By restoring NAD+ availability, the therapy reactivates these protective pathways, improving energy efficiency, reducing oxidative stress, and promoting cellular survival.

NAD+ Restoration Therapy

Meaning

This therapeutic approach is centered on increasing the intracellular levels of Nicotinamide Adenine Dinucleotide (NAD+), a crucial coenzyme involved in hundreds of metabolic processes. NAD+ levels naturally decline with age, contributing to cellular senescence and metabolic dysfunction. Restoration therapy aims to replenish these reserves, thereby supporting mitochondrial function, DNA repair mechanisms, and overall cellular resilience. This intervention is a cornerstone of modern longevity protocols, seeking to improve cellular energy and signaling.