What is the Origin of NAD+ Restoration Science?

The foundational science originates from the discovery of NAD+ and its central role in cellular metabolism, specifically the Krebs cycle and oxidative phosphorylation. The "Restoration Science" aspect gained momentum with the identification of NAD+-dependent enzymes, such as sirtuins and PARPs, and the development of NAD+ precursor molecules like Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN). It represents a targeted strategy within geroscience.

What is the Mechanism of NAD+ Restoration Science?

NAD+ acts as a critical cofactor for numerous enzymes, including Sirtuins, which regulate gene expression related to stress resistance, and Poly-ADP-Ribose Polymerases (PARPs), which are vital for DNA damage repair. By administering NAD+ precursors, the cell's biosynthetic pathways are upregulated, increasing the pool of available NAD+. This restoration enhances mitochondrial function, improves metabolic signaling, and supports the genome's maintenance machinery, effectively buffering against age-related cellular stress.

NAD+ Restoration Science ∞ Area

NAD+ Restoration Science

Meaning

A dedicated field of research and clinical application focused on elevating and maintaining optimal intracellular levels of Nicotinamide Adenine Dinucleotide (NAD+), a crucial coenzyme essential for cellular energy production and DNA repair. The science is driven by the observation that NAD+ levels naturally decline with age, contributing significantly to metabolic dysfunction and the aging process. Interventions aim to counteract this decline to support cellular vitality and metabolic health.