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NAD+ Replenishment Strategies

Meaning

NAD+ replenishment strategies are a suite of therapeutic and nutritional interventions aimed at increasing the intracellular concentration of Nicotinamide Adenine Dinucleotide (NAD+), a crucial coenzyme involved in hundreds of metabolic processes, energy production, and DNA repair. Given that NAD+ levels decline significantly with age, these strategies are a central focus in longevity medicine, seeking to restore the youthful function of sirtuins and PARPs, which are key regulators of cellular resilience and hormonal signaling pathways. Sustaining optimal NAD+ levels is paramount for mitochondrial health and endocrine vitality.