What is the Origin of NAD+ Precursor Administration?

The practice is rooted in decades of biochemical and molecular biology research, which elucidated the central role of NAD+ in cellular energy metabolism and DNA repair. The development of stable, bioavailable precursors has allowed for its clinical application in human health and wellness.

What is the Mechanism of NAD+ Precursor Administration?

NAD+ acts as a crucial cofactor for numerous enzymatic reactions, including those mediated by sirtuins and PARPs, which are essential for DNA repair, gene expression, and cellular stress response. By administering precursors, the body efficiently synthesizes more NAD+, thereby boosting mitochondrial function, enhancing energy production (ATP), and promoting the activity of longevity-associated signaling pathways throughout the endocrine and nervous systems.

NAD+ Precursor Administration

Meaning

NAD+ Precursor Administration is the clinical practice of supplementing with molecules, such as Nicotinamide Riboside (NR) or Nicotinamide Mononucleotide (NMN), that serve as direct building blocks for Nicotinamide Adenine Dinucleotide (NAD+), a critical coenzyme in all living cells. The objective is to elevate intracellular NAD+ levels, which naturally decline with age, to support fundamental metabolic processes and enhance cellular resilience. This strategy is a key component of metabolic and longevity medicine.